diff --git a/django/db/models/expressions.py b/django/db/models/expressions.py
index 444e2fab7b..ced8779637 100644
--- a/django/db/models/expressions.py
+++ b/django/db/models/expressions.py
@@ -902,7 +902,24 @@ class F(Combinable):
         return query.resolve_ref(self.name, allow_joins, reuse, summarize)
 
     def replace_expressions(self, replacements):
-        return replacements.get(self, self)
+        if (replacement := replacements.get(self)) is not None:
+            return replacement
+        field_name, *transforms = self.name.split(LOOKUP_SEP)
+        # Avoid unnecessarily looking up replacements with field_name again as
+        # in the vast majority of cases F instances won't be composed of any
+        # lookups.
+        if not transforms:
+            return self
+        if (
+            replacement := replacements.get(F(field_name))
+        ) is None or replacement._output_field_or_none is None:
+            return self
+        for transform in transforms:
+            transform_class = replacement.get_transform(transform)
+            if transform_class is None:
+                return self
+            replacement = transform_class(replacement)
+        return replacement
 
     def asc(self, **kwargs):
         return OrderBy(self, **kwargs)
diff --git a/tests/constraints/models.py b/tests/constraints/models.py
index 95a29ffa4d..41b827640e 100644
--- a/tests/constraints/models.py
+++ b/tests/constraints/models.py
@@ -73,6 +73,7 @@ class UniqueConstraintProduct(models.Model):
     name = models.CharField(max_length=255)
     color = models.CharField(max_length=32, null=True)
     age = models.IntegerField(null=True)
+    updated = models.DateTimeField(null=True)
 
     class Meta:
         constraints = [
diff --git a/tests/constraints/tests.py b/tests/constraints/tests.py
index 51f09f2937..20a5357cc5 100644
--- a/tests/constraints/tests.py
+++ b/tests/constraints/tests.py
@@ -1,3 +1,4 @@
+from datetime import datetime, timedelta
 from unittest import mock
 
 from django.core.exceptions import ValidationError
@@ -1030,6 +1031,23 @@ class UniqueConstraintTests(TestCase):
             exclude={"name"},
         )
 
+    def test_validate_field_transform(self):
+        updated_date = datetime(2005, 7, 26)
+        UniqueConstraintProduct.objects.create(name="p1", updated=updated_date)
+        constraint = models.UniqueConstraint(
+            models.F("updated__date"), name="date_created_unique"
+        )
+        msg = "Constraint “date_created_unique” is violated."
+        with self.assertRaisesMessage(ValidationError, msg):
+            constraint.validate(
+                UniqueConstraintProduct,
+                UniqueConstraintProduct(updated=updated_date),
+            )
+        constraint.validate(
+            UniqueConstraintProduct,
+            UniqueConstraintProduct(updated=updated_date + timedelta(days=1)),
+        )
+
     def test_validate_ordered_expression(self):
         constraint = models.UniqueConstraint(
             Lower("name").desc(), name="name_lower_uniq_desc"
diff --git a/tests/expressions/tests.py b/tests/expressions/tests.py
index 89601de85b..1fb4e2f34d 100644
--- a/tests/expressions/tests.py
+++ b/tests/expressions/tests.py
@@ -58,10 +58,12 @@ from django.db.models.expressions import (
 from django.db.models.functions import (
     Coalesce,
     Concat,
+    ExtractDay,
     Left,
     Length,
     Lower,
     Substr,
+    TruncDate,
     Upper,
 )
 from django.db.models.sql import constants
@@ -1330,6 +1332,38 @@ class FTests(SimpleTestCase):
         with self.assertRaisesMessage(TypeError, msg):
             "" in F("name")
 
+    def test_replace_expressions_transform(self):
+        replacements = {F("timestamp"): Value(None)}
+        transform_ref = F("timestamp__date")
+        self.assertIs(transform_ref.replace_expressions(replacements), transform_ref)
+        invalid_transform_ref = F("timestamp__invalid")
+        self.assertIs(
+            invalid_transform_ref.replace_expressions(replacements),
+            invalid_transform_ref,
+        )
+        replacements = {F("timestamp"): Value(datetime.datetime(2025, 3, 1, 14, 10))}
+        self.assertEqual(
+            F("timestamp__date").replace_expressions(replacements),
+            TruncDate(Value(datetime.datetime(2025, 3, 1, 14, 10))),
+        )
+        self.assertEqual(
+            F("timestamp__date__day").replace_expressions(replacements),
+            ExtractDay(TruncDate(Value(datetime.datetime(2025, 3, 1, 14, 10)))),
+        )
+        invalid_nested_transform_ref = F("timestamp__date__invalid")
+        self.assertIs(
+            invalid_nested_transform_ref.replace_expressions(replacements),
+            invalid_nested_transform_ref,
+        )
+        # `replacements` is not unnecessarily looked up a second time for
+        # transform-less field references as it's the case the vast majority of
+        # the time.
+        mock_replacements = mock.Mock()
+        mock_replacements.get.return_value = None
+        field_ref = F("name")
+        self.assertIs(field_ref.replace_expressions(mock_replacements), field_ref)
+        mock_replacements.get.assert_called_once_with(field_ref)
+
 
 class ExpressionsTests(TestCase):
     def test_F_reuse(self):