diff --git a/django/core/validators.py b/django/core/validators.py
index 38e4b6aa1d..d32b54f68c 100644
--- a/django/core/validators.py
+++ b/django/core/validators.py
@@ -101,6 +101,7 @@ class URLValidator(RegexValidator):
         r'\Z', re.IGNORECASE)
     message = _('Enter a valid URL.')
     schemes = ['http', 'https', 'ftp', 'ftps']
+    unsafe_chars = frozenset('\t\r\n')
 
     def __init__(self, schemes=None, **kwargs):
         super().__init__(**kwargs)
@@ -108,7 +109,9 @@ class URLValidator(RegexValidator):
             self.schemes = schemes
 
     def __call__(self, value):
-        # Check first if the scheme is valid
+        if isinstance(value, str) and self.unsafe_chars.intersection(value):
+            raise ValidationError(self.message, code=self.code)
+        # Check if the scheme is valid.
         scheme = value.split('://')[0].lower()
         if scheme not in self.schemes:
             raise ValidationError(self.message, code=self.code)
diff --git a/docs/releases/2.2.22.txt b/docs/releases/2.2.22.txt
new file mode 100644
index 0000000000..6808a267af
--- /dev/null
+++ b/docs/releases/2.2.22.txt
@@ -0,0 +1,22 @@
+===========================
+Django 2.2.22 release notes
+===========================
+
+*May 6, 2021*
+
+Django 2.2.22 fixes a security issue in 2.2.21.
+
+CVE-2021-32052: Header injection possibility since ``URLValidator`` accepted newlines in input on Python 3.9.5+
+===============================================================================================================
+
+On Python 3.9.5+, :class:`~django.core.validators.URLValidator` didn't prohibit
+newlines and tabs. If you used values with newlines in HTTP response, you could
+suffer from header injection attacks. Django itself wasn't vulnerable because
+:class:`~django.http.HttpResponse` prohibits newlines in HTTP headers.
+
+Moreover, the ``URLField`` form field which uses ``URLValidator`` silently
+removes newlines and tabs on Python 3.9.5+, so the possibility of newlines
+entering your data only existed if you are using this validator outside of the
+form fields.
+
+This issue was introduced by the :bpo:`43882` fix.
diff --git a/docs/releases/index.txt b/docs/releases/index.txt
index e59c97b17f..4262a97ac1 100644
--- a/docs/releases/index.txt
+++ b/docs/releases/index.txt
@@ -25,6 +25,7 @@ versions of the documentation contain the release notes for any later releases.
 .. toctree::
    :maxdepth: 1
 
+   2.2.22
    2.2.21
    2.2.20
    2.2.19
diff --git a/tests/validators/tests.py b/tests/validators/tests.py
index 36d0b2a520..012b098f4e 100644
--- a/tests/validators/tests.py
+++ b/tests/validators/tests.py
@@ -222,9 +222,15 @@ TEST_DATA = [
     (URLValidator(EXTENDED_SCHEMES), 'git+ssh://git@github.com/example/hg-git.git', None),
 
     (URLValidator(EXTENDED_SCHEMES), 'git://-invalid.com', ValidationError),
-    # Trailing newlines not accepted
+    # Newlines and tabs are not accepted.
     (URLValidator(), 'http://www.djangoproject.com/\n', ValidationError),
     (URLValidator(), 'http://[::ffff:192.9.5.5]\n', ValidationError),
+    (URLValidator(), 'http://www.djangoproject.com/\r', ValidationError),
+    (URLValidator(), 'http://[::ffff:192.9.5.5]\r', ValidationError),
+    (URLValidator(), 'http://www.django\rproject.com/', ValidationError),
+    (URLValidator(), 'http://[::\rffff:192.9.5.5]', ValidationError),
+    (URLValidator(), 'http://\twww.djangoproject.com/', ValidationError),
+    (URLValidator(), 'http://\t[::ffff:192.9.5.5]', ValidationError),
     # Trailing junk does not take forever to reject
     (URLValidator(), 'http://www.asdasdasdasdsadfm.com.br ', ValidationError),
     (URLValidator(), 'http://www.asdasdasdasdsadfm.com.br z', ValidationError),