diff --git a/django/db/models/query.py b/django/db/models/query.py
index 44047d4689..48a7ffbbf1 100644
--- a/django/db/models/query.py
+++ b/django/db/models/query.py
@@ -246,6 +246,9 @@ class QuerySet(object):
             # Add the known related objects to the model, if there are any
             if self._known_related_objects:
                 for field, rel_objs in self._known_related_objects.items():
+                    # Avoid overwriting objects loaded e.g. by select_related
+                    if hasattr(obj, field.get_cache_name()):
+                        continue
                     pk = getattr(obj, field.get_attname())
                     try:
                         rel_obj = rel_objs[pk]
diff --git a/tests/select_related_regress/tests.py b/tests/select_related_regress/tests.py
index f6d21b2dd9..a05ec99074 100644
--- a/tests/select_related_regress/tests.py
+++ b/tests/select_related_regress/tests.py
@@ -173,3 +173,13 @@ class SelectRelatedRegressTests(TestCase):
 
         self.assertEqual(Chick.objects.all()[0].mother.name, 'Hen')
         self.assertEqual(Chick.objects.select_related()[0].mother.name, 'Hen')
+
+    def test_regression_22508(self):
+        building = Building.objects.create(name='101')
+        device = Device.objects.create(name="router", building=building)
+        Port.objects.create(port_number='1', device=device)
+
+        device = Device.objects.get()
+        port = device.port_set.select_related('device__building').get()
+        with self.assertNumQueries(0):
+            port.device.building