diff --git a/django/core/handlers/asgi.py b/django/core/handlers/asgi.py
index 7b0086fb76..46945b41e6 100644
--- a/django/core/handlers/asgi.py
+++ b/django/core/handlers/asgi.py
@@ -19,6 +19,7 @@ from django.http import (
     HttpResponseServerError,
     QueryDict,
     parse_cookie,
+    parsers,
 )
 from django.urls import set_script_prefix
 from django.utils.functional import cached_property
@@ -111,6 +112,10 @@ class ASGIRequest(HttpRequest):
         self._stream = body_file
         # Other bits.
         self.resolver_match = None
+        self._parsers = [
+            parsers.FormParser(),
+            parsers.MultiPartParser(),
+        ]
 
     @cached_property
     def GET(self):
diff --git a/django/core/handlers/wsgi.py b/django/core/handlers/wsgi.py
index 9324af083e..5a372625e2 100644
--- a/django/core/handlers/wsgi.py
+++ b/django/core/handlers/wsgi.py
@@ -3,7 +3,7 @@ from io import IOBase
 from django.conf import settings
 from django.core import signals
 from django.core.handlers import base
-from django.http import HttpRequest, QueryDict, parse_cookie
+from django.http import HttpRequest, QueryDict, parse_cookie, parsers
 from django.urls import set_script_prefix
 from django.utils.encoding import repercent_broken_unicode
 from django.utils.functional import cached_property
@@ -78,6 +78,10 @@ class WSGIRequest(HttpRequest):
         self._stream = LimitedStream(self.environ["wsgi.input"], content_length)
         self._read_started = False
         self.resolver_match = None
+        self._parsers = [
+            parsers.FormParser(),
+            parsers.MultiPartParser(),
+        ]
 
     def _get_scheme(self):
         return self.environ.get("wsgi.url_scheme")
diff --git a/django/http/request.py b/django/http/request.py
index 118cdaeab7..bc9662282e 100644
--- a/django/http/request.py
+++ b/django/http/request.py
@@ -69,6 +69,10 @@ class HttpRequest:
         self.resolver_match = None
         self.content_type = None
         self.content_params = None
+        self._parsers = [
+            parsers.FormParser(),
+            parsers.MultiPartParser(),
+        ]
 
     def __repr__(self):
         if self.method is None or not self.get_full_path():
@@ -417,6 +421,19 @@ class HttpRequest:
     def readlines(self):
         return list(self)
 
+    @property
+    def parsers(self):
+        return self._parsers
+
+    @parsers.setter
+    def parsers(self, parsers):
+        # TODO Also check for _data once added
+        if hasattr(self, "_files"):
+            raise AttributeError(
+                "You cannot change parsers after processing the request's content."
+            )
+        self._parsers = parsers
+
 
 class HttpHeaders(CaseInsensitiveMapping):
     HTTP_PREFIX = "HTTP_"
diff --git a/docs/ref/parsers.txt b/docs/ref/parsers.txt
index 5735bf4b1a..fd732f51e5 100644
--- a/docs/ref/parsers.txt
+++ b/docs/ref/parsers.txt
@@ -56,3 +56,20 @@ Parses HTML form content (). The ``parse()`` method returns a
 
 Parses multipart form content and supports file uploads. The method returns
 a ``QueryDict`` for ``data`` and an ``MultiValueDict`` for ``FILES``.
+
+HttpRequest.Parsers
+===================
+
+``HttpRequest.parsers`` returns a list of parsers to be used when parsing a
+request's content. By default, the parsers list will be Django's included
+parsers (``FormParser, ``MultiPartParser``).
+
+Parsers can be customised by setting a list of parsers to be used on the
+request. This could be in a middleware or in a view, but must be done before
+``data`` or ``FILES`` is accessed. For example:
+
+.. code-block:: python
+
+    def index(request):
+        request.parsers = [MyCustomParser(), FormParser(), ...]
+        ...
diff --git a/tests/requests_tests/test_parsers.py b/tests/requests_tests/test_parsers.py
index 5a1d5653fc..8f23ec3988 100644
--- a/tests/requests_tests/test_parsers.py
+++ b/tests/requests_tests/test_parsers.py
@@ -1,9 +1,12 @@
-from unittest import TestCase
-
+from django.core.handlers.wsgi import WSGIRequest
+from django.http import HttpRequest
 from django.http.parsers import BaseParser, FormParser, MultiPartParser
+from django.test import SimpleTestCase
+from django.test.client import FakePayload
+from django.utils.http import urlencode
 
 
-class TestParsers(TestCase):
+class TestParsers(SimpleTestCase):
     def test_can_handle(self):
         parser = MultiPartParser()
         self.assertIs(parser.can_handle("multipart/form-data"), True)
@@ -25,3 +28,34 @@ class TestParsers(TestCase):
         self.assertIs(parser.can_handle("application/json"), False)
         self.assertTrue(parser.can_handle("text/*"), True)
         self.assertTrue(parser.can_handle("text/csv"), True)
+
+    def test_request_parser_no_setting(self):
+        request = HttpRequest()
+        form, multipart = request.parsers
+        self.assertIsInstance(form, FormParser)
+        self.assertIsInstance(multipart, MultiPartParser)
+
+    def test_set_parser(self):
+        request = HttpRequest()
+        request.parsers = [FormParser()]
+
+        self.assertEqual(len(request.parsers), 1)
+        self.assertIsInstance(request.parsers[0], FormParser)
+
+    def test_set_parsers_following_files_access(self):
+        payload = FakePayload(urlencode({"key": "value"}))
+        request = WSGIRequest(
+            {
+                "REQUEST_METHOD": "POST",
+                "CONTENT_LENGTH": len(payload),
+                "CONTENT_TYPE": "application/x-www-form-urlencoded",
+                "wsgi.input": payload,
+            }
+        )
+        # can set parsers
+        request.parsers = []
+        # access files
+        request.FILES
+        msg = "You cannot change parsers after processing the request's content."
+        with self.assertRaisesMessage(AttributeError, msg):
+            request.parsers = []