diff --git a/django/db/models/base.py b/django/db/models/base.py
index 133adb6f3a..668b8cc221 100644
--- a/django/db/models/base.py
+++ b/django/db/models/base.py
@@ -737,6 +737,11 @@ class Model(AltersData, metaclass=ModelBase):
             if field.is_cached(self):
                 field.delete_cached_value(self)
 
+        # Clear cached private relations.
+        for field in self._meta.private_fields:
+            if field.is_relation and field.is_cached(self):
+                field.delete_cached_value(self)
+
         self._state.db = db_instance._state.db
 
     async def arefresh_from_db(self, using=None, fields=None):
diff --git a/tests/contenttypes_tests/test_fields.py b/tests/contenttypes_tests/test_fields.py
index 170b38d018..418669140b 100644
--- a/tests/contenttypes_tests/test_fields.py
+++ b/tests/contenttypes_tests/test_fields.py
@@ -43,6 +43,14 @@ class GenericForeignKeyTests(TestCase):
             self.assertIsNone(post.parent)
             self.assertIsNone(post.parent)
 
+    def test_clear_cached_generic_relation(self):
+        question = Question.objects.create(text="What is your name?")
+        answer = Answer.objects.create(text="Answer", question=question)
+        old_entity = answer.question
+        answer.refresh_from_db()
+        new_entity = answer.question
+        self.assertIsNot(old_entity, new_entity)
+
 
 class GenericRelationTests(TestCase):
     def test_value_to_string(self):